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A Randomized Controlled Study of the Efficacy of Nutritional Supplementation Combined With Exercise Intervention in Stroke With Sarcopenia

A Randomized Controlled Study of the Efficacy of Nutritional Supplementation Combined With Exercise Intervention in Stroke With Sarcopenia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114117
Enrollment
Unknown
Registered
2025-12-08
Start date
2025-12-09
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Control group:The patient will receive a regular diet and conventional rehabilitation therapy.
Nutritional intervention group:On the basis of the control group, patients will receive additional protein supplementation (Abbott Ensure Plus Whey Protein Solid Beverage).
Comprehensive intervention group:On the basis of the nutritional intervention group, patients will undergo resistance training for the unaffected limb.

Sponsors

Zhujiang Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for stroke and confirmed by CT or MRI; 2. Sarcopenia diagnosed according to the 2023 expert consensus criteria; 3. Age 45-80 years; 4. First-time diagnosis of stroke with a disease duration of 1-12 months, clear consciousness, certain cognitive ability, and ability to cooperate with treatment; 5. Informed understanding and consent to participate in the study by both the patient and their family members; 6. Obtain consent from the patient and their family members and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with clinically unstable conditions such as refractory heart failure, acute myocardial infarction, severe liver or kidney dysfunction, poorly controlled blood pressure or blood glucose, etc.; 2. Patients with a history of mental illness, severe cognitive impairment, or recent severe trauma; 3. Patients with malignant tumors or infectious diseases; 4. Patients unwilling to participate in this study.

Design outcomes

Primary

MeasureTime frame
The Appendicular Skeletal Muscle Index;

Secondary

MeasureTime frame
Body Mass Index;Grip strength of the unaffected side muscles;The Five Times Sit-to-Stand Test ;National Institutes of Health Stroke Scale;Mini-Mental State Examination;Fugl-Meyer Assessment;Modified Barthel Index;Functional Near-Infrared Spectroscopy;

Countries

China

Contacts

Public ContactWang Kangling

Zhujiang Hospital of Southern Medical University

wkangling@126.com+86 159 8920 1852

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026