Various types of myocardial injury
Conditions
Interventions
Observation group 1(Myocardial Injury Study Cohort):None
Observation group 2(Non-myocardial injury study cohort):None
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnostic Criteria: Upon admission, laboratory testing confirms elevated serum/plasma cardiac troponin I (cTnI or cTnT) levels, exceeding the upper limit of the normal reference range (typically > 99%). 2. Age Range: Age > 18 years. 3. Subjects understand and accept the procedures and limitations of this study, and the subject or their legal representative signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Subjects with severe underlying medical conditions, including: malignant tumors, hematological diseases, poisoning, severe malnutrition, HIV/AIDS, active tuberculosis, and autoimmune diseases (such as systemic lupus erythematosus). 3. Patients with severe acute coronary syndrome (AMI, UA), cardiogenic shock, severe chronic heart failure (such as NYHA class IV), or severe valvular heart disease, and whose expected survival is less than 48 hours; 4. Patients currently participating in clinical trials for other drugs; 5. Patients with other factors deemed unsuitable for participation in this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamic measurement of S100A9 expression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of major adverse cardiovascular events (MACE) during hospitalization;Echocardiographic parameters (LVEF, LVEDD) were measured at baseline and day 7;Dynamic changes of S100A9 at day 1, 3, and 5;Length of ICU stay and length of hospital stay; | — |
Countries
China
Contacts
Public ContactPei Hui
The Second Affiliated Hospital of Shandong First Medical University
Outcome results
None listed