?Hemodynamic Instability
Conditions
Interventions
Cipepofol Group (C):1. Anesthesia induction: intravenous bolus of propofol 0.4 mg/kg (injected over >=60 seconds).
2. Anesthesia maintenance: continuous intravenous infusion of propofol, with dosage
continuous intraoperative infusion of remifentanil, with additional sufentanil and/or cisatracurium administered as needed.
Propofol Group (P) :1. Anesthesia Induction: Intravenous (IV) bolus of Propofol 2.0 mg/kg (injection time >=60 seconds).
2. Anesthesia Maintenance: Continuous IV infusion of Propofol, with the dose ti
continuous infusion of Remifentanil during surgery, with supplemental doses of Sufentanil and/or Cisatracurium administered as needed. (Identical to the Ciprofol Group)
Sponsors
The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 60-75 years, no restriction on gender; 2. ASA classification I-III, without cardiovascular complications; 3. Scheduled for elective orthopedic joint (knee/hip) replacement surgery under general anesthesia (expected surgery duration between 1 and 3 hours); 4. BMI at enrollment between 18-30 kg/m^2; 5. Able to understand the study and provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to propofol, soybean, or eggs; 2. Uncontrolled hypertension (systolic BP >=180 mmHg or diastolic BP >=110 mmHg) or preoperative hypotension (MAP 40 g/day) or opioid dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Index (CI);Systemic Vascular Resistance (SVR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure (MAP);Incidence of Hypotension;the dose of vasopressor;Time to Loss of Consciousness (LOC);BIS Value;total consumption of anesthetic ;Extubation Time; | — |
Countries
China
Contacts
Public ContactGuo Fenglin
The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Outcome results
None listed