Corneal endothelial cell dysfunction
Conditions
Interventions
Medication group:Anterior Chamber Perfusion of Nicotinamide
Sponsors
Qingdao Eye Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Aged 18 years or older. Clinically diagnosed with critical stage of corneal endothelial decompensation, accompanied by persistent corneal edema. For the study eye, central corneal thickness (CCT) is >= 620 µm or thicker than the contralateral healthy eye by > 50 µm. Best corrected visual acuity (BCVA) of the study eye ranges from hand motion to 0.5 (decimal visual acuity chart). Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Presence of active ocular surface or intraocular infection/inflammation in the study eye. Complicated with severe glaucoma or active fundus lesions. The study eye is aphakic or has unstable factors such as lax zonular ligaments. Allergy to NAM or any components in the preparation. Pregnant or lactating women. Any uncontrolled systemic diseases. Those unable to attend follow-up visits on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Corneal Endothelial Cell Density;Xin Vaule;BCVA; | — |
Countries
China
Contacts
Public ContactCheng Jun
Qingdao Eye Hospital of Shandong First Medical University
Outcome results
None listed