Immune-Mediated Necrotizing Myopathy
Conditions
Interventions
IMNM group:None
Non-IMNM group:None
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.IMNM Group: (1) Patients with IMNM who are positive for anti-SRP or anti-HMGCR antibodies and meet the 2017 ENMC diagnostic criteria (2) Age 18-75 years ; 2.Non-IMNM Group: (1) Age 18-75 years (2) No recent use of iron supplements or antioxidants;
Exclusion criteria
Exclusion criteria: 1.Comorbid with other connective tissue diseases (such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjögren's syndrome); 2.Severe hepatic or renal dysfunction (Child-Pugh class B or C, creatinine = 1.5 times the upper limit of normal); 3.Active infection, including but not limited to upper respiratory tract infection, pneumonia, urinary tract infection; 4.Recent use (within the past month) of medications affecting iron metabolism/oxidative stress (such as iron supplements, vitamin E, glutathione); 5.Pregnant/lactating women, or patients with malignant tumors; 6.Inability to cooperate with specimen collection or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iron death-related markers (creatine kinase, MMT8 score, MYOACT score; serum ferritin, sTfR, GPX4, SOD, MDA, NERF2, TFRC, etc.); | — |
Countries
China
Contacts
Public ContactLinrong He
China-Japan Friendship Hospital
Outcome results
None listed