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Based on non-targeted serum metabolomics, the study investigated the effects of low-resistance blood flow restriction training on sarcopenic osteoarthritis.

Based on non-targeted serum metabolomics, the study investigated the effects of low-resistance blood flow restriction training on sarcopenic osteoarthritis.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114077
Enrollment
Unknown
Registered
2025-12-08
Start date
2025-12-10
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, sarcopenia

Interventions

BFR-LIRT group:Subjects sit in a seated position. A 10-cm inflatable cuff is placed on the proximal thigh at the inguinal region. Using an ultrasound probe, the posterior tibial artery is identified,
the cuff pressure at this point is defined as the arterial occlusion pressure (AOP). After measuring AOP, the cuff is fully deflated, and subjects rest for 5 minutes. Subsequently, a cuff is applied t

Sponsors

Shanghai Pudong New Area Gongli Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male or female patients aged >=55 years; 2. The myasthenia gravis group meets the diagnostic criteria for the myasthenia gravis group; 3. Voluntarily participated in the study and signed the informed consent form; 4.4. Meets the diagnostic criteria for knee osteoarthritis.

Exclusion criteria

Exclusion criteria: 1. Acute deep vein thrombosis or coagulation disorders; 2. Cardiovascular disease such as uncontrolled hypertension; 3. Presence of recent surgery or trauma to the proposed compression site of the subject limb; 4. Presence of severe peripheral vascular or peripheral neuropathy; 5. The presence of exercise contraindications; 6. Illnesses such as stroke, cranial surgery, major depression, or severe cognitive impairment that interfere with the performance of exercise training; 7. Active cancer; 8. Concurrent participation in other exercise programmes.

Design outcomes

Primary

MeasureTime frame
Serum metabolites;

Countries

China

Contacts

Public ContactWang Zhi

Shanghai Pudong New Area Gongli Hospital

drwangzhi3656@163.com+86 135 6468 3656

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026