Hyperactive Delirium
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine, a maintenance infusion of 0.2-1.4 µg/kg/h was continued until 6:00 AM the next day after achieving the target sedation level.
Chlorpromazine group:Chlorpromazine, a maintenance infusion of 2-15mg/h was continued until 6:00 AM the next day after achieving the target sedation level.
Sponsors
Huashan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients were enrolled if they (1) were aged 18 years or older, and (2) were non-cardiac surgical patients admitted to the ICU who had a positive CAM-ICU assessment and a RASS score ranging from +1 to +4.
Exclusion criteria
Exclusion criteria: ?(1) History of severe dementia or language impairment?; ??(2) History of alcohol abuse?; ??(3) Known left ventricular ejection fraction (LVEF) < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or type II/III heart block without a pacemaker?; ??(4) Expected survival time < 24 hours?; ??(5) History of brain injury or neurosurgery?; ??(6) Pregnancy or lactation?; ??(7) Known contraindications to dexmedetomidine or chlorpromazine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium-free time within 5 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| This study recorded ?the time to reach the target sedation depth? following drug administration.;Daily SOFA scores within 5 days after treatment;Evaluate the longitudinal changes in inflammatory factor levels after administration of the trial drug (measured on Days 1, 3, and 5) and to determine their correlation with the duration of delirium-free time during the study period.;Need for concomitant sedatives and antipsychotics during the ICU period?;Length of ICU stay and Post-ICU hospital stay;30-day all-cause mortality after surgery; | — |
Countries
China
Contacts
Public ContactTong Wu
Huashan Hospital Fudan University
Outcome results
None listed