Inflammatory skin diseases
Conditions
Interventions
Placebo control group:No exercise, only topical placebo.
Control group:No exercise, only topical application of tripalmitoylglycerol.
Exercise placebo group:Moderate-intensity aerobic exercise for 30 minutes daily, with topical application of a placebo.
Exercise Intervention Group:Moderate-intensity aerobic exercise for 30 minutes daily, with topical application of tripalmitoylglycerol.
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Aligns with the latest physical activity standards provided by organizations such as the World Health Organization and the U.S. Department of Health and Human Services in 2023: (1). Inactive: No physical activity of moderate or vigorous intensity beyond daily routine activities; (2). Insufficiently active: Less than 150 minutes of moderate-intensity physical activity or less than 75 minutes of vigorous-intensity physical activity per week; (3). Active: Engages in approximately 150–300 minutes of moderate-intensity physical activity weekly; (4). Very Active: Engages in over 300 minutes of moderate-intensity physical activity weekly. Inactivity and insufficient activity are classified as the control group, while active and very active are classified as the exercise group. 2. Presence of skin barrier damage manifestations (e.g., dry skin, erythema, desquamation, pruritus); 3. Informed consent and voluntary participation; signed informed consent form; 4. Age 18–59 years with generally good health; 5. No medication or probiotic treatment within the past 6 months; 6. Absence of skin diseases or trauma.
Exclusion criteria
Exclusion criteria: 1. History of allergy or hypersensitivity to probiotics, placebo, or study medication; 2. Active skin disease or other severe medical conditions; 3. Pregnant or lactating women; 4. Use of medications that may impair skin barrier function (e.g., corticosteroids, immunosuppressants); 5. Other circumstances deemed unsuitable for inclusion by the investigator, such as subjects who are untrustworthy, unwilling to participate, or unable to comprehend the study assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transepidermal water loss rate of skin;PASI/SCORAD score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of Lipase Activity on the Skin Surface;Palmitoleic acid level detection following glyceride intervention; | — |
Countries
China
Contacts
Public ContactZhang Jianglin
Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and Techno )
Outcome results
None listed