Degenerative diseases of the lumbar spine
Conditions
Interventions
Experimental Group One:Experimental Group 1 received a 50 mg/kg intravenous infusion of TXA (diluted in 100 ml saline) 15 minutes prior to surgical skin incision. During surgery, a maintenance dose of
Experimental Group Two:Experimental Group 2 received a 50 mg/kg intravenous infusion of TXA (diluted in 100 ml saline) 15 minutes prior to surgical skin incision. with a maintenance dose of 10mg/kg·h
dosage selected based on the number of fusion segments, with 3U of bacitracin required per segment).
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients requiring lumbar TLIF surgery for giant disc herniation, recurrent disc herniation, intervertebral pseudoarthrosis, and symptomatic lumbar spondylolisthesis; 2. Patients are >=18 years old and <=80 years old; 3. Patients agree to participate in this study and sign the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing secondary revision surgery; 2. Patients with a history of cardiovascular or cerebrovascular accidents, or those with severe underlying cardiovascular or cerebrovascular conditions rendering them unsuitable for surgery; 3. Patients with severe anaemia or coagulation disorders preoperatively; 4. Patients allergic to TXA or bartitin; 5. Patients with severe hepatic or renal insufficiency; 6. Patients with a history of thrombosis (e.g., DVT or PE); 7. Patients still taking anticoagulants (e.g., aspirin) within two weeks prior to surgery; 8. Intraoperative dura mater injury resulting in cerebrospinal fluid leakage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in fibrinolytic parameters;Occult blood loss;Postoperative drainage volume;Maximum haemoglobin loss;Length of hospital stay;Incidence of complications; | — |
Countries
China
Contacts
Public ContactLiu Limin
West China Hospital, Sichuan University
Outcome results
None listed