Moyamoya Disease
Conditions
Interventions
Experimental Group:The drug will be administered via intravenous infusion. The dosing regimen consists of a loading dose of 1.0 µg/kg infused over 15 minutes upon entry to the operating room, followed
Control group:The control group will receive an equal volume of 0.9% sodium chloride injection (normal saline) instead of dexmedetomidine.
Sponsors
Shanghai Punan Hospital of Pudong New District
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The diagnosis was confirmed by conventional digital subtraction angiography, magnetic resonance imaging, CT angiography and CT perfusion examination, and met the relevant diagnostic criteria. 2. Age > 18 years old; 3. No contraindications for surgery; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Combined with brain and autoimmune diseases such as meningitis and intracranial tumors; 2. Combined with disorders of important organs such as the liver and kidneys; 3. There is a history of cerebral hemorrhage within 3 months before the operation; 4. Severe hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate;Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;National Institutes of Health Stroke Scale Score;Cerebral hyperperfusion syndrome;Outcome name: Postoperative complications (e.g., seizure, neurological deterioration, intracranial hemorrhage);Length of hospital stay; | — |
Countries
China
Contacts
Public ContactWeidong Chen
Shanghai Punan Hospital of Pudong New District
Outcome results
None listed