Colorectal tumor
Conditions
Interventions
Control Group:At the end of the surgery, an intravenous injection of an equivalent volume of normal saline was administered, and an analgesic pump filled with 100 ml of normal saline containing sufent
Intervention Group:At the end of the surgery, an intravenous injection of nalmefene (0.25 µg/kg) was administered, and an analgesic pump containing a solution diluted to 100 ml with normal saline (nal
Sponsors
Xuancheng City People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Willing to sign the informed consent form; 2.Patients scheduled to undergo elective laparoscopic or open colorectal surgery under general anesthesia; 3.18 years or older; 4.American Society of Anesthesiologists (ASA) physical status I-III; 5.Willing to receive postoperative intravenous patient-controlled analgesia (IV-PCA).
Exclusion criteria
Exclusion criteria: 1.Known allergy or hypersensitivity to nalmefene; 2.Presence of severe cardiovascular disease; 3.History of opioid dependence or chronic opioid use; 4.Pre-existing severe gastrointestinal dysfunction; 5.Planned use of other continuous regional anesthesia techniques (e.g., epidural analgesia); 6.Presence of severe hepatic or renal insufficiency; 7.Scheduled for an emergency or re-operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first defecation;Postoperative pain;Postoperative gastrointestinal function;Length of Stay (LOS);Postoperative adverse events; | — |
Countries
China
Contacts
Public ContactYang Yun
Xuancheng City People's Hospital
Outcome results
None listed