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The Value of 18F-CD8+ PET/CT Imaging in Predicting the Efficacy of Immunotherapy for Malignant Tumors: A Prospective Clinical Cohort Study

The Value of 18F-CD8+ PET/CT Imaging in Predicting the Efficacy of Immunotherapy for Malignant Tumors: A Prospective Clinical Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114018
Enrollment
Unknown
Registered
2025-12-05
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who undergo immunotherapy based on clinical judgment or their own request

Interventions

Sponsors

Peking University Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Study participants voluntarily participate in this trial and sign the informed consent form; 2.Aged >= 18 years and <= 80 years (based on the date of signing the informed consent form), with no restriction on gender; 3.Patients newly diagnosed with malignant tumors and patients scheduled to receive immunotherapy after radiotherapy and chemotherapy; 4.Physical fitness status score: 0~1 point; 5.The expected survival time is more than 12 months; 6.Female study participants of childbearing age, male study participants, and the partners of male study participants agree to use reliable contraceptive methods (such as abstinence, sterilization surgery, contraceptive pills, injectable contraceptive medroxyprogesterone, or subcutaneous implant contraception, etc.) within 6 months after the end of the last study drug infusion; 7.Willing and able to comply with scheduled visits, diagnostic plans, clinical laboratory tests, and other trial procedures.

Exclusion criteria

Exclusion criteria: 1.Previous use of radionuclides with an interval of less than 10 physical half-lives from the time of drug administration in this study; 2.Currently undergoing or planning to participate in any drug or device clinical trial during the study period; 3.Unable to lie flat or remain still during a PET scan, or intolerant of PET scans; 4.Those with a history of fracture or anemia in the past year; 5.Participants had abnormalities in physical examinations, ECG, and clinical laboratory tests during the screening period.

Design outcomes

Primary

MeasureTime frame
Maximum standardized uptake value;

Countries

China

Contacts

Public ContactDong Mengjie

Peking University Shenzhen Hospital

Dongmengjie@126.com+86 182 5717 3283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026