Vaginal Laxity
Conditions
Interventions
Control group aged 18–30 years (Study 1):None
Control group aged 31–40 years (Study 1):None
Control group aged 41–50 years (Study 1):None
Vaginal delivery group aged 18–30 years (Study 1):None
Vaginal delivery group aged 31–40 years (Study 1):None
Vaginal delivery group aged 41–50 years (Study 1):None
Healthy postmenopausal women aged 51–59 years (Study 1):None
Healthy postmenopausal women aged 60–65 years (Study 1):None
Control group (Study 2):None
Mild vaginal laxity group:None
Moderate vaginal laxity group:None
Severe vaginal laxity group:None
Sponsors
Peking University Shenzhen Hospita
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Study 1 1.Women aged 18–65 years 2.No complaint of vaginal laxity and VLQ score >= 4 3.Vaginal introitus admitting = 6 months that negatively impacts quality of life 3. Vaginal Laxity Questionnaire (VLQ) score <=3 4. Gynecologic digital examination showing moderate-to-severe laxity (i.e., vagina easily accommodates three or four fingers) 5. Able to understand the study and voluntarily provide written informed consent.
Exclusion criteria
Exclusion criteria: Study 1 1.Currently pregnant, breastfeeding, or = stage II (POP-Q stage > I) 4. Moderate-to-severe stress urinary incontinence (SUI) or other bothersome urinary incontinence requiring treatment 5. Major pelvic surgery (e.g.hysterectomy, pelvic-floor reconstruction, anti-incontinence procedures) 6. History of pelvic malignancy or pelvic radiotherapy 7. Known systemic disorders affecting connective tissue or muscle function (e.g.Ehlers-Danlos syndrome, Marfan syndrome, systemic lupus erythematosus, multiple sclerosis) 8. Acute genital-tract infection at time of assessment 9. Imaging showing large pelvic masses that distort pelvic-floor anatomy (e.g. uterine fibroids or ovarian cysts > 5 cm) 10. Current use of hormonal medications affecting estrogen levels (e.g.oral contraceptives, hormone-replacement therapy) 11. Unable to tolerate trans-vaginal ultrasound or perform a Valsalva maneuver Study 2 1. Pregnancy, breastfeeding, or = III), as it constitutes a distinct disease entity that would severely confound measurements 3. Previous pelvic-floor reconstruction, anti-incontinence, or vaginal cosmetic surgery 4. History of pelvic malignancy or radiotherapy. 5. Systemic disorders affecting connective tissue or neuromuscular function. 6. Acute genital tract infection. 7. Inability to complete questionnaires or cooperate with ultrasound examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasonic elastic modulus of the vaginal wall; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal wall thickness;Microcirculation Quantification;Levator ani hiatus; | — |
Countries
China
Contacts
Public ContactWang Yue
Peking University Shenzhen Hospital
Outcome results
None listed