Poor ovarian response
Conditions
Interventions
Control Group:Following the conventional protocol, proceed to the IVF cycle.
SVF Group:On the day of the surgery, the first procedure was the lower abdominal fat aspiration (100ml, with the actual amount to be determined), which was used to prepare SVF. The cells within the SV
the amount of cells administered to each ovary was (1-2) × 107 per side. There were 3 administration points on each ovary, with 330 ± 10 µl at each point, and the total volume of administration for ea
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Women who have fertility requirements and are seeking IVF treatment at the Reproductive Medicine Center of Peking University Third Hospital 2. Age = 1 year 3. Meeting the diagnostic criteria for POI or the Poseidon diagnostic criteria for POR 4. Previous controlled ovarian stimulation resulted in no more than 3 oocytes retrieved and/or no transplantable embryos and/or previous embryo implantation failure >= 2 times 5. Uterus and bilateral adnexa are intact 6. BMI 22 - 29 kg/m^2 7. Participants must have given informed consent for this study and voluntarily signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Congenital abnormalities of reproductive organs 2. Septicemia, platelet dysfunction syndrome and severe thrombocytopenia and other coagulation disorders or other hematological diseases 3. Suffering from autoimmune diseases or other endocrine diseases, with abnormal thyroid function and uncontrolled condition 4. Having a mass in the adnexal area with an unclear benign or malignant nature 5. Complicated with severe cardiovascular and cerebrovascular diseases, malignant tumors, hematological diseases and mental disorders, patients with impaired function of important organs 6. Those who have used systemic corticosteroids within the last 2 weeks, or used antiplatelet drugs such as aspirin within the last 48 hours 7. In the acute inflammatory stage 8. Those with a history of venous thrombosis or pulmonary embolism during the screening period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of retrieved oocytes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood anti-Müllerian hormone (AMH) level;Number of antral follicles (AFC);clinical pregnancy rate; | — |
Countries
China
Contacts
Public ContactCaihong Ma
Peking University Third Hospital
Outcome results
None listed