Depressive syndrome
Conditions
Interventions
Elderly Depression Group without Cognitive Decline:None
Elderly Depression Group with Cognitive Decline:None
Sponsors
Beijing An Ding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria for the Elderly Depression Group: 1. All meet the diagnostic criteria for depression in DSM-5; 2. Aged >= 60 years, regardless of gender; 3. Age of onset >= 55 years; 4. Score of 24-item Hamilton Depression Rating Scale (HAMD-24) >= 20; 5. No history of electroconvulsive therapy (ECT) in the past 3 months; 6.Right-handed. Inclusion Criteria for the Mild Cognitive Impairment (MCI) Group: 1. Diagnosis of MCI is based on the 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders: (1). Cognitive impairment reported by the patient or informant, or identified by experienced clinicians; (2). Objective evidence of impairment in one or more cognitive domains (confirmed by cognitive tests);(3). Mild impairment in complex instrumental activities of daily living may be present, while independent basic activities of daily living are maintained; d. Does not meet the diagnostic criteria for dementia;2. Aged >= 60 years, regardless of gender;3. Score of 24-item Hamilton Depression Rating Scale (HAMD-24) <= 8; 4. No history of mental illness in the past; 5. Right-handed.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for the Elderly Depression Group: 1. Mental disorders caused by organic diseases; 2. Positive signs detected in neurological examinations; 3. History of abuse of alcohol, drugs, or other psychoactive substances; 4.Patients comorbid with other neurological diseases or severe physical diseases. Exclusion Criteria for the Mild Cognitive Impairment (MCI) Group: 1. Stroke episodes (including a clear history of previous cerebral infarction, cerebral hemorrhage episodes, and acute-stage stroke); 2. Positive signs detected in neurological examinations; 3. History of abuse of alcohol, drugs, or other psychoactive substances; 4. Patients comorbid with other neurological diseases or severe physical diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain network connection strength and topological properties; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prediction accuracy of cognitive decline using multimodal brain network features.; | — |
Countries
China
Contacts
Public ContactZhang Xinqiao
Beijing An Ding Hospital, Capital Medical University
Outcome results
None listed