Major Depressive Disorder
Conditions
Interventions
SSRI control group:Take citalopram as an example. Take it orally every day for 4 weeks, starting at 20 mg/day. If the HAMD-17 score doesn’t decrease by 50%, increase the dose by 20 mg every 2 - 4 week
SSRI+rTMS treatment group:The TMS protocol will adhere to the consensus recommendations of the NNDC TMS Task Force and the APA CoR Novel Biomarkers and Treatments Task Force. USFDA - approved paramete
SSRI+MECT treatment group:MECTA spECTrum 5000Q device will be used at 800 milliamperes. The seizure threshold for each patient will be determined via stimulus titration. Under right unilateral setup,
Sponsors
The Affiliated Kangning Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 13--70 years old. 2. Education: At least junior high school level, able to read and understand documents like the informed consent form and self - assessment scales independently. 3. Diagnosis: Patients diagnosed with depression based on ICD - 10 criteria. 4. Contraception: Women of childbearing potential must use two contraceptive methods, confirmed by the research team. 5. Participation consent: Patients and their family members agree to participate in the project and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with schizophrenia, bipolar disorder, personality disorders, or other severe mental illnesses per ICD-10. 2. History of alcohol or drug abuse. 3. Severe neurological diseases, such as epilepsy, stroke, or brain tumors. 4. History of severe head injury with neurological sequelae. 5. Patients with severe physical, infectious, or immune system diseases. 6. Contraindications for MRI, including pregnancy/breastfeeding, cardiac pacemakers, cerebral aneurysm clips, ferromagnetic implants, artificial metal heart valves, metal joints, or insulin pumps/nerve stimulators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactTiansheng Zheng
The Affiliated Kangning Hospital of Wenzhou Medical University
Outcome results
None listed