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Integrating Real-World Data for AI-Driven Pharmacodynamic Modeling of Drug Interactions in Precision Anesthesia

Integrating Real-World Data for AI-Driven Pharmacodynamic Modeling of Drug Interactions in Precision Anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113944
Enrollment
Unknown
Registered
2025-12-04
Start date
2025-12-07
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

general anesthesia

Interventions

Validation:None

Sponsors

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective non-cardiac and non-neurosurgical procedures under general anesthesia, including general surgery, orthopedics, gynecology, neurosurgery, thoracic surgery, hepatobiliary surgery, urology, vascular surgery, and otorhinolaryngology–head and neck surgery; 2. Age between 18 and 85 years; 3. ASA physical status classification I–IV; 4. Expected surgery duration >= 60 minutes.

Exclusion criteria

Exclusion criteria: 1. Patients with diseases affecting EEG acquisition, such as poisoning, epilepsy or related syndromes, central nervous system infection, ischemic or hypoxic encephalopathy, neurodegenerative disorders (including Alzheimer’s disease, Lewy body dementia, Parkinson’s disease, Huntington’s disease), or cortical dysplasia; 2. Patients undergoing burn surgery, organ transplantation, cesarean section, or emergency operations; 3. Patients who refuse to sign informed consent.

Design outcomes

Primary

MeasureTime frame
BIS (Bispectral Index);TOF (train-of-four);NoL (nociception level);HRV (Heart rate variability);Drug plasma concentration;GOF (goodness-of-fit);pcVPC (prediction-corrected visual predictive check);

Countries

China

Contacts

Public ContactPei Lijian

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

hazelbeijing@vip.163.com+86 186 1267 2127

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026