Depression disorder
Conditions
Interventions
Group with the traditional target :Transcranial magnetic stimulation treatment based on the traditional 5-cm targeting method.
Individualized targeting group:Personalized treatment guided by biological subtypes
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria:? (1) Age between 12 and 18 years; (2) Meet DSM-5 diagnostic criteria for major depressive disorder (MDD), confirmed by the Mini International Neuropsychiatric Interview for Children and Adolescents (M.I.N.I.-KID); (3) Score =22 on the Montgomery-Åsberg Depression Rating Scale (MADRS) at baseline.
Exclusion criteria
Exclusion criteria: Exclusion Criteria:?? (1) Comorbid psychiatric disorders including schizophrenia, schizoaffective disorder, bipolar disorder, or obsessive-compulsive disorder; (2) Significant neurological disorders (e.g., epilepsy, stroke, encephalitis, traumatic brain injury) or severe systemic illnesses (e.g., malignant tumors, acute heart failure, multi-organ failure); (3) Contraindications to MRI scanning (e.g., metallic implants, claustrophobia); (4) History of electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), or bright light therapy within the past 6 months; (5) Alcohol or substance use disorders within the preceding year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale;Hamilton Depression Rating Scale;Columbia-Suicide Severity Rating Scale; Patient Health Questionnaire-9;Generalized Anxiety Disorder-7;Beck Scale for Suicide Ideation ;Snaith-Hamilton Pleasure Scale ;Magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactZhang Bin
Tianjin Anding Hospital
Outcome results
None listed