Epidemic cerebrospinal meningitis
Conditions
Interventions
Intervention Group 1:Receive the ACYW group quadrivalent meningococcal conjugate vaccine.
Intervention Group 2:Receive the AC group bivalent meningococcal conjugate vaccine.
Control group:Receive the bivalent meningococcal polysaccharide vaccine of the AC group under the National Immunization Program.
Sponsors
Immunization Program Center, Chinese Center for Disease Control and Prevention
Eligibility
Sex/Gender
All
Age
3 Years to 4 Years
Inclusion criteria
Inclusion criteria: 1.Children aged 3 and above but under 4 years old; 2. Have received two doses of MPCV-AC within 12 months of age; 3. Has not received any third dose of meningococcal vaccine; 4. The guardians of the children give informed consent and participate voluntarily.
Exclusion criteria
Exclusion criteria: 1. Have a history of chronic diseases (such as immune system dysfunction, kidney disease, neurological disorders, metabolic diseases, etc.); 2. Suffering from congenital diseases, such as congenital heart disease, congenital immune deficiency, etc. 3. Have received immunoglobulin or blood product treatment within the three months prior to the study; 4. Have a history of meningococcal meningitis; 5. At the time of investigation, the individual suffered from moderate to severe acute diseases, infections or febrile diseases (axillary temperature >37.3?); 6. There are contraindications to vaccination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bactericidal Antibody Titers against neisseria meningitidis of Serogroup A;Bactericidal Antibody Titers against neisseria meningitidis of Serogroup C;Serum IgG antibody concentration of Neisseria meningitidis group A;Serum IgG antibody concentration of Neisseria meningitidis group C; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-2;Interleukin-7;Interferon-?; | — |
Countries
China
Contacts
Public ContactZheng Hui
Immunization Program Center, Chinese Center for Disease Control and Prevention
Outcome results
None listed