Cancer-related cognitive dysfunction
Conditions
Interventions
Longitudinal investigation group:None
CCRT intervention group:computer-assisted cognitive rehabilitation therapy and Usual care
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Study Sample Cross-sectional study inclusion criteria: Patients with a confirmed cancer diagnosis (head and neck cancers, thoracic cancers, abdominal cancers, brain tumors); aged 18-60 years; able to hear, speak, read, and write; right-handed; previously normal cognitive function; primary school education or higher; voluntary participation; signed informed consent. Longitudinal study inclusion criteria: Patients newly diagnosed with cancer who undergo cognitive function assessments at preoperative, postoperative, and 1, 3, 6, and 12 months after radiation or chemotherapy. Inclusion criteria: Pathologically confirmed cancer via biopsy or intraoperative frozen section (head and neck, thoracic, abdominal cancers); Stage I-II; requiring surgical resection; aged 18-60 years; able to hear, speak, read, and write; right-handed; previously normal cognitive function; primary school education or higher; voluntary participation; signed informed consent. 2. Intervention Sample Inclusion criteria: (1) Patients diagnosed with cancer for the first time within the past 6 months; (2) Currently receiving active anti-cancer treatment (surgery, chemotherapy, radiotherapy); (3) Aged 18-60 years; (4) Junior high school education or higher with normal hearing, speaking, vision, and cognitive abilities, able to understand the information sheet and consent form; (5) Proficient in using smartphones to access the internet at home or work.
Exclusion criteria
Exclusion criteria: 1. Exclusion Criteria for Longitudinal Study (1) Patients with severe suicidal ideation or severe impulsive behavior at present; (2) History of other severe psychiatric disorders; (3) History of alcohol or other substance dependence or abuse; (4) Systematic use of any antipsychotic medication or systematic psychotherapy within the past year. 2. Exclusion Criteria for Intervention Group (1) Patients diagnosed with Stage IV cancer, recurrent metastatic cancer, or hematological malignancies; (2) Patients with severe suicidal ideation or severe impulsive behavior at present; (3) History of other severe psychiatric disorders; (4) History of alcohol or other substance dependence or abuse; (5) Systematic use of any antipsychotic medication or systematic psychotherapy within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Assessment of Cancer Therapy-Cognitive Function, Version 3;functional near-infrared spectroscopy;Hospital Anxiety and Depression Scale;European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edmonton Symptom Assessment Scale;Skin electrophysiological reflex; | — |
Countries
China
Contacts
Public ContactYang Yang
The First Hospital of Shanxi Medical University
Outcome results
None listed