Dentition Defect
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Patients requiring extraction of bilateral homologous healthy teeth for therapeutic purposes. (2) Age between 14 and 25 years (inclusive). (3) General symmetry in occlusion and alveolar bone structure between left and right sides. (4) No history of bone metabolic diseases, hematological diseases, mental disorders, or uncontrolled systemic conditions. (5) No history of smoking, with good patient compliance. (6) Willingness to undergo all evaluations specified in the trial protocol. (7) Agreement to sign the informed consent form approved by the Ethics Committee
Exclusion criteria
Exclusion criteria: (1) Contraindications to tooth extraction. (2) Presence of bone metabolic diseases, hematological diseases, mental disorders, uncontrolled systemic diseases, or use of medications that may affect soft/hard tissue healing, coagulation function, or pain/anxiety levels. (3) History of trauma with alveolar bone plate fracture or defect. (4) Patients in the acute phase of any disease. (5) Patients with severe periodontal diseases. (6) Incomplete or poor-quality radiographic documentation. (7) Inability to cooperate with treatment or poor compliance. (8) History of alcohol abuse or long-term substance misuse. (9) History of smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in buccal alveolar bone height in the extraction area as determined by CBCT at the 3-month follow-up.;Differences in the changes of extraction socket size measured at the 7-day and 14-day postoperative follow-ups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in lingual bone plate height changes in the extraction area as determined by CBCT at the 3-month follow-up;Differences in alveolar socket width at levels 1 mm, 3 mm, and 5 mm apical to the line connecting the highest points of the buccal and lingual bone plates, as determined by CBCT at the 3-month follow-up;Difference in bone density as determined by CBCT at the 3-month follow-up;Differences in the changes of facial swelling measured at the 2-day and 7-day postoperative follow-ups;Differences in the soft tissue healing index score as assessed at the 7-day postoperative follow-up; | — |
Countries
China
Contacts
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine