Benign and malignant tumors of the liver
Conditions
Interventions
The experimental group (non-VVB group):The experimental group (non-VVB group) will undergo TVE and in-situ hypothermic portal perfusion without the use of VVB.
The control group (VVB group):The control group (VVB group) will undergo VVB combined with TVE and in-situ hypothermic portal perfusion
Sponsors
Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of complex liver lesions involving the first or second hepatic hilum or inferior vena cava, with a planned liver resection. 2.Planned liver resection under total hepatic vascular exclusion with an anticipated occlusion time of less than 90 minutes. 3.Patients who meet surgical criteria and have no other severe comorbidities. 4.Good liver function with a future liver remnant volume >40%, and eligibility for liver resection under portal vein in-situ hypothermic perfusion. 5.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Distant metastatic disease. 2.Severe heart, lung, kidney, or other organ dysfunction. 3.Uncontrolled malignant tumors before or after surgery. 4.Anticipated vascular occlusion time >90 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Long-term Survival;Progression-Free Survival;R0 Resection Rate;90-Day Mortality Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operative Time;Blood Loss;Ischemia Time;Postoperative Complications;Postoperative Liver and Renal Function Recovery;Postoperative Gastrointestinal Function Recovery; | — |
Countries
China
Contacts
Public ContactZhang Yu
Sichuan Provincial People's Hospital
Outcome results
None listed