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Analysis of the Real-world Efficacy and Safety of Cross-line Treatment with Immune Checkpoint Inhibitors in Patients with Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Clinical Study

Analysis of the Real-world Efficacy and Safety of Cross-line Treatment with Immune Checkpoint Inhibitors in Patients with Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Clinical Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113885
Enrollment
Unknown
Registered
2025-12-04
Start date
2024-11-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

Observation Group of Immune cross-line therapy:None

Sponsors

The First Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Only patients who meet all of the following inclusion criteria and do not meet any of the exclusion criteria can be enrolled in this study: (1) Patients diagnosed with esophageal squamous cell carcinoma by pathology or clinical diagnosis; (2) Patients who have received immune checkpoint inhibitors during first-line and second-line treatments; (3) Patients aged 18 or above; (4) Patients with complete medical record data and follow-up information;

Exclusion criteria

Exclusion criteria: (1) Patients with missing data and information related to key research; (2) Patients with the second primary cancer;

Design outcomes

Primary

MeasureTime frame
Second-line progression-free survival;

Secondary

MeasureTime frame
First-line progression-free survival; 1-year PFS1 rate; 1-year PFS2 rate;Objective response rate;Disease control rate;Duration of relief;Overall survival;The total number of inpatient days;

Countries

China

Contacts

Public ContactDao Xin

The First Affiliated Hospital of Zhengzhou University

xd105982@163.com+86 185 3003 4310

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026