Sepsis
Conditions
Interventions
Control group:Vagus nerve pseudostimulation
Experimental Group:Vagus nerve electrical stimulation
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.18 to 80 years old; 2. Meet the sepsis diagnostic criteria 3.0 jointly formulated by the American Academy of Critical Care Medicine and the European Academy of Critical Care Medicine in 2016: The patient has an infection and the SOFA score is >=2 points; 3. Admitted to the ICU within one week after the onset of sepsis; 4. Obtain the informed consent of the patient and/or his/her guardian;
Exclusion criteria
Exclusion criteria: 1.Severe ARDS defined by PaO2/FiO2 =5 cm H2O; 2.HR>120 per minute; 3.Epinephrine or norepinephrine >1ug/kg/min; 4.Severe underlying pulmonary diseases including interstitial lung disease, diffuse alveolar hemorrhage, severe asthma, or lung cancer; 5.TaVNS contraindications: existing pacemakers, cochlear implants, or other active implantable electronic medical devices; 6.Dermatologic or infectious disorders affecting the auricular region; 7.Pregnancy or lactation; 8.Participation in other clinical trials; 9.Inability to remain motionless during treatment (e.g., due to epilepsy or Parkinson's disease);
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Glasgow coma scale;Arterial blood gas (ABG) analysis;Blood routine;Respiratory dynamic parameters;Vasoactive-intropic score; | — |
Primary
| Measure | Time frame |
|---|---|
| SOFA score; | — |
Countries
China
Contacts
Public ContactHou Jingming
The First Affiliated Hospital of Army Medical University
Outcome results
None listed