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Effects of an Early Mobilization Protocol on Outcomes in Difficult-to-Wean Mechanically Ventilated Patients: A Randomized Controlled Trial

Effects of an Early Mobilization Protocol on Outcomes in Difficult-to-Wean Mechanically Ventilated Patients: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113862
Enrollment
Unknown
Registered
2025-12-04
Start date
2025-12-14
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early rehabilitation of ICU patients

Interventions

Experimental group:Patients in the intervention group, based on the nursing care provided to the control group, carried out early active activities according to the assessment criteria of the early ac
Control group:Provide nursing care and treatment according to the standard practices of the intensive care unit

Sponsors

The First Hospital of Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old; 2. The patient meets the criteria for difficult weaning; 3. The patient was able to move independently before admission (BI score >= 70); 4. The patient is conscious and can cooperate with the medical staff; 5. The patient and their family members have given informed consent.

Exclusion criteria

Exclusion criteria: 1. Respiratory system: Patients undergoing high-frequency oscillatory ventilation (HFOV) and prone position ventilation; 2. Orthopedic system: Unstable fractures; 3. Nervous system: Rapidly progressing neuromuscular diseases, cervical spinal cord injury, severe traumatic brain injury; 4. Cardiovascular and cerebrovascular system: Hypertensive emergencies requiring intravenous antihypertensive drugs to control, acute cardiovascular and cerebrovascular diseases; 5. Others: Patients with severe open trauma to the chest/rib cage or abdomen, patients with uncontrolled active bleeding that has been determined, extensive burns, during CRRT treatment, lower extremity venous and arterial thrombosis.

Design outcomes

Primary

MeasureTime frame
The incidence of delirium;Grade of voluntary coughing force;

Secondary

MeasureTime frame
The rate of re-intubation within 48 hours after extubation of tracheal intubation;The rate of returning to the ICU within 48 hours after being transferred out;Mechanical ventilation duration;Length of stay in the ICU and total hospital stay;

Countries

China

Contacts

Public ContactZhang Zhigang

The First Hospital of Lanzhou University

zzg3444@163.com+86 139 1909 3444

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026