Hysteroscopy
Conditions
Interventions
Ciprofol + High-flow group:Induction: High-flow oxygen at 10 L/min for 10 minutes pre-oxygenation + intravenous infusion of dexmedetomidine 1 µg/kg over 10 minutes
Induction: Oxygen flow adjusted to 60 L/min, Sufentanil 0.1 µg/kg + Ciprofol 0.2–0.4 mg/kg
Maintenance: Ciprofol 0.4–0.6 mg/(kg·h) + Dexmedetomidine 5 ml/h
Ciprofol + Nasal Cannula group: Induction: Nasal cannula 6 L/min with 10 minutes pre-oxygenation + pump infusion of dexmedetomidine 1 µg/kg over 10 minutes
Induction: Nasal cannula 6 L/min, sufentanil 0.1 µg/kg + ciprofol 0.2–0.4 mg/kg
Maintenance: Ciprofol 0.4–0.6 mg/(kg·h) + dexmedetomidine 5 ml/h
Propofol + High-flow group: Induction: High-flow oxygen at 10 L/min for 10 minutes pre-oxygenation + intravenous infusion of dexmedetomidine 1 µg/kg over 10 minutes
Induction: Oxygen flow adjusted to 60 L/min, sufentanil 0.1 µg/kg + propofol 1–2 mg/kg
Maintenance: Propofol 2–4 mg/(kg·h) + dexmedetomidine 5 ml/h
Ciprofol + Nasal Cannula group:Pre-induction: Nasal cannula 6 L/min with 10 minutes pre-oxygenation + intravenous infusion of dexmedetomidine 1 µg/kg over 10 minutes
Induction: Nasal cannula 6 L/min, sufentanil 0.1 µg/kg + propofol 1-2 mg/kg
Maintenance: Propofol 2-4 mg/(kg·h) + dexmedetomidine 5 ml/h.
Sponsors
Baoding First Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 18–80 years; BMI >= 28 kg/m^2; ASA physical status classification I/II.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Coagulation disorders or a tendency to epistaxis; Diagnosed respiratory conditions including asthma, bronchitis, emphysema, or chronic obstructive pulmonary disease; History of allergy to intravenous anaesthetics or opioid analgesics; Respiratory tract infection within the preceding two weeks; Two consecutive preoperative measurements of systolic blood pressure (SBP) > 180 mmHg and/or diastolic blood pressure (DBP) > 110 mmHg; Patients with severe obstructive sleep apnoea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Blood oxygen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Time of successful anaesthetic induction;Time to wakefulness after discontinuation of medication;Total dose of ciprofol and propofol;Adverse events during induction (cough, hypotension, injection site pain, bradycardia) and number of supplementary induction sessions;The incidence of postoperative nausea and vomiting, uterine contractions (lower abdominal pain accompanied by a sensation of anal heaviness), and adverse events associated with high-flow nasal cannula oxygen therapy.;Physician satisfaction and patient satisfaction; | — |
Countries
China
Contacts
Public ContactZhu Lei
Baoding First Central Hospital
Outcome results
None listed