Reduced postoperative blood loss
Conditions
Interventions
Group A:Intraoperative intravenous tranexamic acid
Group B:Intraoperative local injection of tranexamic acid
Group C:Intraoperative intravenous and local combined administration of tranexamic acid
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with symptomatic medial compartment knee osteoarthritis accompanied by varus deformity requiring correction via high tibial osteotomy. 2. Normal joint range of motion 3. ASA physical status classification I–III 4. Osteotomy spread angle between 8–12° 5. Patients who signed informed consent prior to the study 6. Kellgren-Lawrence classification grade 2–3
Exclusion criteria
Exclusion criteria: 1. Patients allergic to tranexamic acid 2. Patients with a history of coagulation disorders 3. History of venous thromboembolism 4. Patients with preoperative hemoglobin <100g/L; those still on anticoagulant therapy preoperatively 5. Severe cardiovascular or cerebrovascular disease 6. Patients who have used antiplatelet agents within 7 days prior to surgery 7. Patients who have used thrombolytic agents within 7 days prior to surgery 8. Severe hepatic or renal dysfunction 9. Use of medications with blood-thinning or blood-concentrating effects during the perioperative period 10. Patients who have used hemostatic agents or hemostatic plasma products within 7 days prior to surgery, or who experienced major hemorrhage within one month prior to surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreased hemoglobin values;specific volume of red blood cells;Size of hematoma on ultrasound;Perioperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sleep quality score;Postoperative VAS score;Postoperative Anxiety Scale Score;C-reactive protein count;Quality of Life Score at Two Months Post-Surgery; | — |
Countries
China
Contacts
Public ContactLina Zhao
Department of Anesthesiology, Tianjin Hospital
Outcome results
None listed