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Metabolomic Characteristics of Postmenopausal Stress Urinary Incontinence and the Mechanisms of Radiofrequency Therapy

Metabolomic Characteristics of Postmenopausal Stress Urinary Incontinence and the Mechanisms of Radiofrequency Therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113833
Enrollment
Unknown
Registered
2025-12-03
Start date
2025-12-08
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress urinary incontinence

Interventions

Group A: menopause >= 1 year, without SUI.:None
Group B: menopause >=1 year, with SUI:Radiofrequency Therapy

Sponsors

Xiangya Third Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
45 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Age: >= 45 years; (2) Physiological stage: menopause >= 1 year; (3) SUI diagnosis: ICIQ-SF score >= 1 plus a positive cough stress test; (4) POP-Q stage: <= II.

Exclusion criteria

Exclusion criteria: (1) Metabolic diseases: diabetes, unresolved history of gestational diabetes, hypertension, thyroid dysfunction, polycystic ovary syndrome, hyperlipidemia, metabolic syndrome, or obesity (BMI >= 35). (2) Medication interference: use of antibiotics, hormonal medications, or nutritional supplements within the past 3 months. (3) Special dietary patterns: extreme dieting, high-protein supplementation (protein powder), vegetarian diet, alcohol abuse, or a history of smoking. (4) Hormonal status: persistently elevated prolactin (lactation period) or use of oral contraceptives. (5) Pelvic floor structural abnormalities: POP >= stage III, bladder prolapse, history of severe perineal tear repair, or prior pelvic surgery. (6) Neurological conditions: confirmed pudendal nerve injury, neurogenic bladder, or a history of spinal cord injury. (7) Vaginal microecological abnormalities: positive for trichomonas, candida, or HPV; use of vaginal medications or sexual intercourse within the past 3 days. (8) Defecation problems: chronic constipation. (9) Other symptoms: overactive bladder (OAB), urgency urinary incontinence (UUI), or mixed urinary incontinence (MUI).

Design outcomes

Primary

MeasureTime frame
ICIQ-UI-SF;I-QOL;Posture assessment;Vaginal microbiota;Thyroid function;Complete blood count;Sex hormones;Blood lipids;Liver function;

Secondary

MeasureTime frame
Pelvic floor function assessment;Rectus abdominis assessment;

Countries

China

Contacts

Public ContactYanhua Zhou

Xiangya Third Hospital of Central South University

42351847@qq.com+86 139 7516 3438

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026