Surgical patients
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine 100µg/1ml was diluted with normal saline to 25ml, resulting in a concentration of 4µg/ml. After anesthesia induction, a loading dose of 0.05ml/kg (0.2µg/kg dexmed
Esketamine Group:Esketamine 50mg/2ml was diluted with normal saline to 25ml, resulting in a concentration of esketamine 2mg/ml. After anesthesia induction, a loading dose of 0.05ml/kg (0.1 mg/kg esket
Dexmedetomidine-esketamine Group:Dexmedetomidine 100µg/1ml, esketamine 50mg/2ml, diluted with normal saline to 50ml, with a concentration of dexmedetomidine 4µg/ml and esketamine 2mg/ml
after anesthesia induction, a loading dose of 0.05ml/kg (0.2µg/kg dexmedetomidine and 0.1mg/kg esketamine) was administered at a rate of 20ml/h, followed by a continuous infusion at a rate of 0.05ml/k
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. Scheduled for surgery under general anesthesia, with an estimated operation time > 1 hour; 3. Postoperative patient-controlled intravenous analgesia pump required.
Exclusion criteria
Exclusion criteria: 1. Patients unable to communicate preoperatively due to visual, auditory, verbal, or other reasons; 2. Patients with severe bradycardia (HR < 50 bpm), sick sinus syndrome, grade 2 or higher atrioventricular block, and without a pacemaker implantation; 3. Patients with a history of hyperthyroidism or pheochromocytoma preoperatively; 4. Patients with a history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension preoperatively; 5. Patients who have undergone intracranial tumor surgery or neurosurgical procedures; 6. Patients with severe liver dysfunction (Child-Pugh class C), renal failure (requiring renal replacement therapy), or ASA class = IV; 7. Patients participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery on the first day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery status on the third day post-surgery; | — |
Countries
China
Contacts
Public ContactKun Wang
Peking University First Hospital
Outcome results
None listed