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Clinical and Basic Research on MP Resistance and Pathogenesis in the Context of MPP Outbreak in Autumn 2023

Clinical and Basic Research on MP Resistance and Pathogenesis in the Context of MPP Outbreak in Autumn 2023

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113806
Enrollment
Unknown
Registered
2025-12-03
Start date
2023-10-30
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mycoplasma pneumoniae pneumonia

Interventions

Observation Group of Mycoplasma pneumoniae Pneumonia Infection:None

Sponsors

The First Hospital of Jilin University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: (1) Meeting the indications for bronchoalveolar lavage, performed in accordance with the "2018 Chinese Pediatric Flexible Bronchoscopy Guidelines" expert consensus. (2) Positive MP DNA in the bronchoalveolar lavage fluid of children with MPP. (3) Detection of MP sequences in the bronchoalveolar lavage fluid of children with MPP through tNGS (transcriptional next-generation sequencing). (4) Positive MP IgM antibody in the blood of children with MPP. Meeting any one of the three criteria (2), (3), or (4), in addition to criterion (1), is sufficient for inclusion in the study.

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) Patients with contraindications to bronchoalveolar lavage such as heart failure, severe arrhythmias, severe pulmonary insufficiency, and acute respiratory failure. (2) Patients with comorbidities involving the hematologic system, rheumatic autoimmune diseases, or other systemic diseases that may interfere with diagnosis and treatment. (3) Patients who cannot tolerate bronchoscopy procedures and discontinue treatment. (4) Patients allergic to medications used during bronchoscopy, such as anesthetics. (5) Patients who transfer hospitals or discontinue treatment mid-way through their hospital stay, or those with incomplete clinical data. (6) Patients participating in other research studies simultaneously with this study. (7) Patients who initially agree but later refuse to provide samples or refuse cooperation.

Design outcomes

Primary

MeasureTime frame
Genome sequencing;Drug sensitivity test results;

Countries

China

Contacts

Public ContactMan Gao

The First Hospital of Jilin University

gao_man@jlu.edu.cn+86 158 4409 7051

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026