Postoperative Nausea and Vomiting
Conditions
Interventions
Tegliadine Fumarate Group:0.02 mg/kg Tegliadine administered intravenously during induction, and 0.01 mg/kg Tegliadine administered intravenously 10 minutes before skin closure.
Sufentanil Citrate Group:0.02 µg/kg Sufentanil administered intravenously during induction, and 0.01 µg/kg Sufentanil administered intravenously 10 minutes before skin closure
Sponsors
Department of Anesthesiology, Taizhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, female patients; 2. ASA physical status classification ?–?; 3. Patients identified as being at high risk of postoperative vomiting (preoperative Apfel score = 3); 4. Body Mass Index (BMI) 18.5-30 kg/m²; 5. Hospital stay > 48 hours; 6. Surgical duration < 2 hours.
Exclusion criteria
Exclusion criteria: 1. Inability to communicate preoperatively due to cognitive impairment or language barrier; ?2. Preoperative history of chronic pain or opioid abuse; ?3. Patients with preoperative gastrointestinal or other related diseases prone to causing vomiting; ?4. History of drug use and/or alcohol abuse within the past 3 months; ?5. Patients who are expected to be unable to assess pain intensity postoperatively or to be transferred to the ICU; 6. Patients with expected intraoperative blood loss > 1000 ml or other serious complications during surgery; ?7. Severe systemic diseases involving the heart, lungs, liver, kidneys, etc.; ?8. Patients with central nervous system diseases or mental system disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale Score for Postoperative Nausea and Vomiting ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Nausea and Vomiting Incidence;Numerical Rating Scale Pain Score;Recovery Room Stay Duration;Ramsay Sedation Scale Score;Quality of Recovery-15 Scale Score;Postoperative Satisfaction Score;Postoperative Adverse Reactions; | — |
Countries
China
Contacts
Public ContactWang Wenwei
Department of Anesthesiology, Taizhou First People's Hospital
Outcome results
None listed