Lipid metabolism disorders
Conditions
Interventions
Aerobic exercise:The aerobic exercise group first underwent peak oxygen uptake testing. Following the test, participants performed single-session exercises at intensities of 40%-50%, 50%-60%, 60%-70%,
Resistance exercise:The resistance training group first underwent 1RM tests for squats, deadlifts, and bench presses. Following the tests, participants performed single-repetition exercises at 40%-50%
Combined exercise:The exercise regimen for the aerobic and resistance training groups involved performing 30 minutes of resistance training followed by 30 minutes of aerobic exercise, three times per
Control group:The control group maintained their original lifestyle and dietary habits without any exercise intervention.
Sponsors
Beijing Sport Universitiy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Dyslipidemia (LDL-C >=3.4 mmol/L/HDL-C =1.7 mmol/L); 2.Carotid ultrasound showing IMT >1.0mm or local IMT exceeding 50% of surrounding normal vessel wall thickness; 3. Currently not receiving lipid-lowering medication; 4. No history of cardiac surgery such as coronary artery bypass grafting; 5. No regular exercise in the past 6 months, defined as <60 minutes of moderate-to-vigorous physical activity per week based on self-reported physical activity questionnaire; 6. No musculoskeletal issues; 7. Not pregnant or breastfeeding.
Exclusion criteria
Exclusion criteria: 1. Patients with a confirmed diagnosis of cardiovascular disease (such as coronary heart disease, heart failure, severe arrhythmia), poorly controlled hypertension (such as systolic blood pressure >200 mmHg), diabetes, etc.; 2. Presence of any absolute contraindications to exercise, such as acute infection, recent myocardial infarction, aortic dissection, severe renal insufficiency, etc. Individuals with musculoskeletal or neurological disorders affecting exercise capacity, or those who recently underwent lower extremity arterial surgery; 3. Recent (e.g., within 3 months) ongoing use of cardiovascular medications or drugs affecting metabolism; 4. Individuals with a recent (e.g., within 6 months) history of regular exercise habits (e.g.,>=60 minutes per week of moderate-to-vigorous physical activity); 5. Pregnant or lactating women; 6. Presence of severe organ failure, malignancy, cognitive or psychiatric disorders precluding study compliance, orother conditions deemed unsuitable for study participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wall shear stress;Oscillation Index;Blood flow-mediated endothelium-dependent relaxation function;Pulse Wave Velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rayleigh index;ß Index;Elastic Modulus;Total Cholesterol, Triglycerides, High-Density Lipoprotein Cholesterol, Low-Density Lipoprotein Cholesterol; | — |
Countries
China
Contacts
Public ContactZhou Huayi
Beijing Sport University
Outcome results
None listed