Swallowing Disorders After Subcortical Stroke
Conditions
Interventions
rTMS + rPMS stimulation group:High-frequency rTMS stimulation: Using a figure-of-8 coil, the stimulation site was located at the affected M1 area. Parameters: frequency 10 Hz, intensity 80% of the res
rTMS Sham + rPMS Active Group:rTMS Sham Stimulation: A figure-of-8 coil was used. The equipment, stimulation parameters, and stimulation site were identical to those in the rTMS active stimulation gro
rTMS Sham + rPMS Sham Group:rTMS Sham Stimulation: A figure-of-8 coil was used. The equipment, stimulation parameters, and stimulation site were identical to those in the rTMS active stimulation group
Sponsors
The Fifth Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for Healthy Subjects: (1) Aged between 30 and 85 years (inclusive); (2) In good general health with independent mobility; (3) No swallowing disorders; (4) No cognitive or speech impairments; (5) No severe diseases of the heart, lungs, liver, pancreas, kidneys, or other organs; (6) No metal implants in the body; (7) Ability to follow instructions for examinations and voluntarily provide signed informed consent. 2. Inclusion Criteria for Patients with Post-Subcortical Stroke Dysphagia: (1) Aged between 30 and 85 years (inclusive); (2) Unilateral subcortical stroke (ischemic or hemorrhagic) confirmed by cranial CT or MRI; (3) Kubota Water Swallow Test score = Grade 3 (Can swallow 30ml of warm water at once, but with coughing); (4) Stable vital signs (The specific criteria are as follows: heart rate 60-100 beats per minute, blood pressure 90-140/60-90 mmHg, respiratory rate 15-25 breaths per minute, and oxygen saturation >95%); (5) Ability to follow instructions for examinations and voluntarily provide signed informed consent
Exclusion criteria
Exclusion criteria: 1. Healthy Subjects Exclusion Criteria: (1) History of neurological disorders such as stroke, intracranial tumors, intracranial infections, Parkinson's disease, etc.; (2) Structural abnormalities of the oral cavity, pharynx, or esophagus; history of oropharyngeal and/or cervical surgery; or dysphagia caused by other diseases; (3) Use of gastrointestinal prokinetic agents, H2 receptor blockers, sedatives, analgesics, antidepressants, or anticholinergic drugs within 1 month prior to enrollment; (4) History of severe claustrophobia (previous episodes of claustrophobia); (5) Inability to cooperate or refusal to sign the informed consent form; (6) Pregnant women; (7) Other conditions deemed by the investigator to potentially affect the study evaluation or safety, such as uncontrolled cough symptoms. 2. Exclusion Criteria for Patients with Subcortical Stroke and Dysphagia: (1) Comorbid intracranial tumors, intracranial infections, Parkinson's disease, or other neurological disorders; (2) Structural abnormalities of the oral cavity, pharynx, or esophagus; history of oropharyngeal and/or cervical surgery; or dysphagia caused by other diseases; (3) History of epilepsy; (4) Presence of metal implants in the body; (5) Psychiatric disorders or severe claustrophobia (previous episodes of claustrophobia); (6) Pregnant women; (7) Cognitive impairment or aphasia; (8) Inability to cooperate or refusal to sign the informed consent form; (9) Other conditions deemed by the investigator to potentially affect the study evaluation or safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Oral Intake Scale,FOIS;Rosenbek penetration aspiration scale, PAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Swallowing temporality;Kinematic and temporal parameters;Activation of regions of interest and functional connectivity strength; | — |
Countries
China
Contacts
Public ContactLuo Zirui
The Fifth Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed