Knee Osteoarthritis
Conditions
Interventions
Dry Needling Group (DG):Ultrasound-guided trigger point dry needling(6 times)
The platelet-rich plasma group (PG):Ultrasound-guided trigger point dry needling(6 times) combined with PRP injection method(3 times)
Sponsors
East China Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
Female
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria for patients with knee osteoarthritis (KOA) are as follows: 1. Must meet the clinical diagnostic criteria of the American College of Rheumatology (ACR); 2. Age should be over 50 years old; 3. Confirmed by imaging examination to be at Kellgren-Lawrence (K-L) stage II to IV; 4. Have experienced knee joint pain for most of the past month (>= 15 days); 5. Baseline Numerical Pain Rating Scale (NPRS) score should be >=4 points (using a 0-10 scale); 6. And there should be at least one activated myofascial trigger point (MTrPs) in the target muscle groups such as the quadriceps, hamstring, or gastrocnemius; 7. For patients with bilateral knee arthritis, the side with a higher K-L stage will be selected as the target assessment and treatment side. If the bilateral stages are the same, the side with a higher NPRS score will be chosen.
Exclusion criteria
Exclusion criteria: 1. Within 3 months, received glucocorticoid injections into the knee joint cavity or received hyaluronic acid treatment within 6 months; 2. Previously received autologous blood products (such as platelet-rich plasma) or stem cell therapy; 3. Had systemic rheumatic diseases (such as rheumatoid arthritis, ankylosing spondylitis) or acute inflammatory diseases; 4. Had abnormal coagulation function (International Normalized Ratio INR > 1.5 or platelet count < 150×10^9/L) or was using anticoagulant/antiplatelet drugs (including aspirin, warfarin, and clopidogrel, etc.); 5. And had limited independent walking ability (defined as unable to complete the 10-meter walking test without assistive devices) or had cognitive impairment affecting the research assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical Pain Rating Scale(NPRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Range of Motion, ROM;Quantitative assessment of leg lean mass (dual-energy X-ray absorptiometry (DXA);Peak Torque, PT(Isokinetic muscle strength testing); | — |
Countries
China
Contacts
Public ContactYantao Ma
East China Hospital Affiliated to Fudan University
Outcome results
None listed