Postoperative Gastrointestinal Function in Laparoscopic Surgery
Conditions
Interventions
Tegileridine Fumarate Group (Group T):Tegileridine for analgesic therapy after surgery
Sufentanil group (Group S):Sufentanil for analgesic therapy after surgery
Sponsors
The Affiated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years, any gender, BMI 18.5–27 kg/m^2; 2. ASA classification I–III; 3. Elective laparoscopic surgery; 4. Use of a postoperative analgesia pump; 5. Signed informed consent and able to cooperate with follow-up.
Exclusion criteria
Exclusion criteria: 1. Preexisting chronic gastrointestinal diseases (such as intestinal obstruction, inflammatory bowel disease); 2. Hepatic or renal dysfunction (Child-Pugh class B or above, eGFR =III or LVEF =160/100 mmHg]; acute coronary syndrome or stroke within the past 6 months); 4. Preoperative use of medications affecting gastrointestinal function; 5. History of opioid allergy, chronic pain, or chronic opioid use (daily opioid use >=3 months or morphine >=60 mg/day and use >=1 month); 6. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of motilin, vasoactive intestinal peptide (VIP), and acetylcholine (ACh) in intestinal tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative gastrointestinal function score (I-FEED);Postoperative first exhaust time, first time getting out of bed, first time eating;Analgesic effect: total and effective compressions of analgesic pump within 48 hours after surgery, NRS score (resting, exercise), postoperative rescue analgesia time, frequency, drug type, dosage;Adverse reaction incidence: nausea, vomiting, respiratory depression ,hypotension;Hospitalization costs and length of stay; | — |
Countries
China
Contacts
Public ContactLiu Jing
The Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed