Postoperative pain
Conditions
Interventions
Control group:Postoperative analgesia using morphine
Experimental group:Postoperative analgesia using tegileridine fumarate
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Understand the trial, comprehend and be able to cooperate with its procedures, have good communication skills, voluntarily participate, and sign the written informed consent form; 2. Aged 18-65 years, any gender; 3. Body Mass Index (BMI) between 18.0 kg/m^2 and 28.0 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification I to II; 5. Scheduled for thoracoscopic surgery under general anesthesia, with an expected surgery duration of 1 to 6 hours.
Exclusion criteria
Exclusion criteria: 1. Allergic to opioids or nonsteroidal anti-inflammatory drugs, or having contraindications to them; 2. Severe liver or kidney dysfunction (Child-Pugh class C, or eGFR 10 mg/day of oxycodone, continuously >2 weeks) or psychiatric medications; 5. History of substance abuse (drugs or alcohol); 6. Pregnant or breastfeeding women; 7. Participation in other drug clinical trials within the past 3 months; 8. Other conditions deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain score (NRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Remedial analgesia;PCA pump dosage and effective number of pump presses;Anxiety, depression and sleep quality assessment;Postoperative recovery;Adverse events; | — |
Countries
China
Contacts
Public ContactZhang Jiaqiang
Henan Provincial People's Hospital (Zhengzhou University People's Hospital)
Outcome results
None listed