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Mesenchymal Stem Cell-Derived Exosomes in Neuropathic Pain: Therapeutic Potential and Mechanism of Action——G protein-coupled receptor 35 of the anterior cingulate cortex alleviates neuropathic pain and depression-like behavior

Mesenchymal Stem Cell-Derived Exosomes in Neuropathic Pain: Therapeutic Potential and Mechanism of Action

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113757
Enrollment
Unknown
Registered
2025-12-02
Start date
2023-05-16
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic pain

Interventions

Neuropathic pain Group:None
Control Group:None

Sponsors

The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Case group 1. Partcipants with lumbar intervertebral disc protrusion compressing the sciatic nerve and causing lower extremity pain; 2. Conscious and able to cooperate with blood drawing; 3. Age between 18 and 80 years old; 4. ASA I-III grade; 5. Individuals and their families voluntarily participate in this project. Control group: healthy individual

Exclusion criteria

Exclusion criteria: 1. With chronic diseases such as hypertension and diabetes mellitus; 2. Lumbar intervertebral disc protrusion has been operated on; 3. Uncooperative for blood drawing; 4. ASA > III; 5. Individuals and his/her family refused to participate in this project.

Design outcomes

Primary

MeasureTime frame
The expression level of GPR35 in blood;—

Countries

China

Contacts

Public ContactJianling Xu

The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)

xujl6028@163.com+86 182 5537 8731

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026