Early Puberty Development
Conditions
Interventions
High exposure group to ALAN:NA
Low exposure group to ALAN:NA
Sponsors
Peking University Health Science Center
Eligibility
Sex/Gender
All
Age
8 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. 8-10 years old at baseline survey 2. The development of secondary sexual characteristics has not yet entered the second stage of Tanner 3. The child and guardian agree to sign the informed consent for the follow-up investigation 4. There is no transfer plan within 2 years
Exclusion criteria
Exclusion criteria: 1. Tanner Phase II has been entered at the time of baseline investigation 2. Those with abnormal physical development (such as dwarfism, gigantism, etc.) 3. Those with physical disability and deformity, such as severe scoliosis, chicken breast, lameness, etc 4. Those with major organ diseases (such as heart disease, liver disease, kidney disease, etc.) 5. Those with endocrine diseases, such as diabetes, hyperthyroidism or insufficiency, other endocrine diseases, etc 6. Those who do not agree to participate in the secondary sex screening and follow-up survey
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Breast development level;E2;TT;FSH;LH; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;kisspeptin; | — |
Countries
China
Contacts
Public ContactYi Song
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China
Outcome results
None listed