Diabetic foot
Conditions
Interventions
Group B:Intravenous infusion of remimazolam
Group A:Intravenous infusion of dexmedetomidine
Sponsors
Huzhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18–75 years, any gender; 2. Anesthesia ASA classification II–III; 3. Fasting blood glucose controlled between 4.0–11.0 mmol/L; 4. Body mass index (BMI) normal (18.5–30 kg/m^2); 5. Voluntarily agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe respiratory and circulatory system diseases; 2. Coagulation dysfunction (including PT, INR, and APTT exceeding 1.5 times the normal value, platelet count below 80×10^9/L); 3. History of allergic reaction to local anesthetics; 4. History of drug abuse (including opioids and psychoactive drugs); 5. History of peripheral nerve injury in the lower limbs and infection at the operation site; 6. Vulnerable groups.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress-related physiological parameters (including mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO?), respiratory rate (RR), etc.);Patient and healthcare provider satisfaction assessment;Assessment of intraoperative stress levels;Postoperative recovery quality;Postoperative pain intensity; | — |
Countries
China
Contacts
Public ContactTang Yawen
Huzhou Central Hospital
Outcome results
None listed