Knee Osteoarthritis
Conditions
Interventions
Knee osteoarthritis group (Phase I):None
Control group(Phase I):None
Exposure group (Phase II):None
Control group (Phase II):None
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 80 Years
Inclusion criteria
Inclusion criteria: Phase I: Cross-sectional Study Knee Osteoarthritis (KOA) Group: 1. Admitted to the Department of Orthopedics, Peking University Shougang Hospital for knee-related surgery; 2. Age >= 25 years; 3. Diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria; 4. Kellgren-Lawrence (K-L) grade 1–3; 5. Provided informed consent. Control Group: 1. Admitted to the Department of Orthopedics, Peking University Shougang Hospital for knee-related surgeries (including meniscal injury, cruciate ligament injury, patellar subluxation, loose body in the knee joint, or popliteal cyst); 2. Age >= 25 years; 3. Knee osteoarthritis definitively excluded based on the American College of Rheumatology (ACR) criteria; 4. Provided informed consent. Phase II: Cohort Study (Subjects are all individuals at high risk for KOA) 1. Age >= 40 years, regardless of gender; 2. Employee of Qian'an Iron and Steel Company; 3. Presence of obesity, overweight, or a history of knee joint trauma; 4. Radiographic examination confirmed absence of radiographic knee osteoarthritis (diagnostic definition refer to section 4.2.1); 5. Provided informed consent and voluntarily agreed to participate in this study.
Exclusion criteria
Exclusion criteria: Phase I: Cross-sectional Study KOA Group: 1. Presence of rheumatic and immunological diseases such as rheumatoid arthritis or ankylosing spondylitis that may cause lower limb joint disorders; 2. Patients with confirmed lower extremity venous thrombosis or other conditions that prevent completion of PWV examination; 3. Presence of severe cerebrovascular disease, peripheral neurovascular lesions, or other internal medical conditions that may affect lower limb mobility and normal function; 4. History of significant knee injury; 5. Conditions such as deafness, muteness, or psychiatric disorders that may impair normal communication ability; 6. Inability to complete follow-up visits on schedule; 7. Planning pregnancy or currently pregnant during the study period; 8. Deemed unsuitable for participation in the study for other reasons as determined by the investigator. Control Group: 1. Presence of rheumatic and immunological diseases such as rheumatoid arthritis or ankylosing spondylitis that may cause lower limb joint disorders; 2. Patients with confirmed lower extremity venous thrombosis or other conditions that prevent completion of PWV examination; 3. Presence of severe cerebrovascular disease, peripheral neurovascular lesions, or other internal medical conditions that may affect lower limb mobility and normal function; 4. Conditions such as deafness, muteness, or psychiatric disorders that may impair normal communication ability; 5. Inability to complete follow-up visits on schedule; 6. Planning pregnancy or currently pregnant during the study period; 7. Deemed unsuitable for participation in the study for other reasons as determined by the investigator. Phase II: Cohort Study 1. Presence of mental disorders, limited language ability, or other reasons that prevent independent reading or acceptance of follow-up; 2. Presence of knee pain or tenderness; 3. Patients with lower extremity venous thrombosis (unable to undergo PWV examination).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee joint X-ray examination;Brachial-Ankle Pulse Wave Velocity;Laboratory Examination;Diagnosis of incident KOA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic demographic information;All-cause mortality;CVD events; | — |
Countries
China
Contacts
Public ContactYuan Ping
Peking University Shougang Hospital
Outcome results
None listed