Cardiac surgery with cardiopulmonary bypass
Conditions
Interventions
Experimental Group:After the central venous catheter is induced and placed under general anesthesia, 2.5g of tranexamic acid is diluted into 100ml of warm saline, and after the main operation of cardi
Control group:Patients in the control group received the current standard clinical antifibrinolytic therapy protocol. Specifically:
Loading dose: After general anesthesia induction and central venous
Sponsors
People's Hospital of Xinjiang Uygur Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Male or female aged 18-70; (2) undergoing cardiopulmonary bypass heart surgery; (3) Signed written informed consent;
Exclusion criteria
Exclusion criteria: (1) Acquired color vision disorder; (2) Patients with active intravascular coagulation; (3) Those who have a history of convulsions or epilepsy in the past; (4) Allergy or contraindication to tranexamic acid injection or its components; (5) Lactating or pregnant women; 6) End-stage disease, with an estimated survival of less than 3 months; (7) Mentally or legally disabled patients; (8) concurrent participation in another perioperative interventional study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative allogeneic red blood cell transfusion rate;Composite endpoint of major clinical events at 30 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume of allogeneic red blood cell transfusion postoperation;Coagulation Function;Thromboelastography (TEG);Rate of rethoracotomy for hemostasis;Duration of postoperative mechanical ventilation;Volume of postoperative drainage;Length of ICU stay postoperation;Postoperative hospital stay;Total hospitalization cost; | — |
Countries
China
Contacts
Public ContactYan Lei
People's Hospital of Xinjiang Uygur Autonomous Region
Outcome results
None listed