Central nervous system infectious diseases
Conditions
Interventions
Suspected Central Nervous System Infectious Diseases Group:No interventions.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Presence of symptoms or signs consistent with central nervous system infection (one or more): fever, headache, vomiting, seizures, focal neurological deficits, behavioral abnormalities, impaired consciousness, meningeal irritation signs, etc.; 2. Age>=18 years; 3. Completion of lumbar puncture with successful collection of sufficient cerebrospinal fluid (CSF); 4. Fulfillment of at least one of the following criteria: a. Elevated intracranial pressure (>200 mmH2O); b. Increased CSF white blood cell count (>5 × 106/L); c. Elevated CSF protein level (>0.45 g/L); d. Decreased CSF glucose level (10 × 10?/L with neutrophil proportion >80%; g. Neuroimaging suggestive of possible infection; h. Failure to meet any of the above seven criteria, but effective response to empirical anti-infection therapy.
Exclusion criteria
Exclusion criteria: 1. Patient refusal of lumbar puncture, presence of contraindications to lumbar puncture, or insufficient cerebrospinal fluid (CSF) obtained; 2. Confirmed diagnosis of infectious diseases in other systems or non-infectious central nervous system diseases (e.g., autoimmune encephalitis, tumors, cerebrovascular disorders, etc.); 3. Severely incomplete clinical information; 4. Final diagnosis not confirmed with poor response to empirical anti-infection therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebrospinal Fluid Pathogen Detection results;Sensitivity (true positive rate);Specificity (true negative rate);Accuracy (crude agreement rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| False positive rate;False negative rate;Youden index;Likelihood ratio;Additional detection rate;ROC curve; | — |
Countries
China
Contacts
Public ContactZhen Hong
West China Hospital, Sichuan University
Outcome results
None listed