High-grade squamous intraepithelial lesion
Conditions
Interventions
Gold Standard:Colposcopic pathological results
Index test:Autofluorescence Colposcopy
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Women aged 18 to 65 years with a history of sexual activity; 2.Patients with suspicious medical history or signs, such as contact bleeding, abnormal vaginal discharge, abnormal cervical appearance, etc.; those with abnormal screening results, such as cytology showing ASCUS with positive HPV test, cytology showing LSIL or above, or positive for HPV type 16/18; 3.No history of cervical cancer or cervical physical therapy, with a complete cervix; 4.Not in the menstrual period and no sexual intercourse or intravaginal medication within 48 hours; 5.No acute inflammation in the vagina or cervix; 6.Willing to participate in the study after providing informed consent.
Exclusion criteria
Exclusion criteria: 1.Cervical dysplasia (including congenital malformations, didelphys uterus); 2.History of cervical treatment (including conization, ablation, photodynamic therapy, etc.); 3.With definite immunosuppressive conditions, such as HIV infection or organ transplantation,; 4.Patients with severe hemorrhagic diseases such as coagulation disorders, or photosensitive diseases; 5.With concurrent cancer at other sites or a history of radiotherapy or chemotherapy (e.g., pelvic radiotherapy, etc.); 6.The patient is in pregnancy or puerperium; 7.Other conditions deemed inappropriate for the study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histopathological results of colposcopic biopsy; | — |
Countries
China
Contacts
Public ContactWei Wang
Shanghai First Maternity and Infant Hospital
Outcome results
None listed