stroke
Conditions
Interventions
Group 1: iTBS(600 pulses +1200 sham stimulation)
Group 3:iTBS (1800 pulses)
Group 4:false iTBS(1800 sham stimulation)
Group 2: iTBS(1200 pulses +600 sham stimulation)
Sponsors
Shanghai Second Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis met the diagnostic criteria of "Key points for the Diagnosis of Major cerebrovascular Diseases in China 2019" and was confirmed by head CT or MRI; 2. First occurrence of unilateral cerebral hemisphere cerebral infarction/cerebral hemorrhage, patients with cerebral hemorrhage had not undergone head surgery; 3. Age of 55-85 years old; 4. The course of disease was 3-12 months; 5. There is moderate to severe motor dysfunction, the proximal part of the hemiplegic side FMA-UE score is less than 26 points, and the conventional neuromodulation effect is not good; 6. Patients or their immediate family members understood and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with unstable condition and unstable vital signs; 2. Patients who could not tolerate iTBS treatment; 3. Patients with previous Parkinson's disease, peripheral neuropathy and other motor dysfunction; 4. Combined with tumor, serious diseases of respiratory, cardiac, hepatic, renal, endocrine and hematopoietic systems; 5. Pregnant and lactating women; 6. Patients with a history of epilepsy or family history of epilepsy, metal pacemakers, metal implants in the brain, cochlear implants, and skull defects who are not suitable for transcranial magnetic stimulation; 7. Patients who were enrolled in other clinical trials or had recently received neuromodulation therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Near Infrared (fNIRS) Detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment-Upper Extremity;modified Ashworth Scale, MAS;modified Barthel Index,MBI; | — |
Countries
China
Contacts
Public ContactCheng Xie
Shanghai Second Rehabilitation Hospital
Outcome results
None listed