Neonatal respiratory distress syndrome (NRDS) is caused by deficiency or dysfunction of pulmonary surfactant, leading to progressive atelectasis, decreased lung compliance, and ventilation–perfusion mismatch. Clinically, it presents as rapidly worsening respiratory distress shortly after birth. It is most common in preterm infants but can also occur in infants of diabetic mothers, those born by ce
Conditions
Interventions
Case Group:None
Healthy control group:None
Sponsors
The Second Affiliated hospital of Fujian Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnancy complications group: Singleton pregnancy, 20-36 weeks of gestation, meeting one of the following diagnoses: Gestational hypertension: Guidelines for the Diagnosis and Treatment of Gestational Hypertension Diseases of the Obstetrics and Gynecology Branch of the Chinese Medical Association Hypertension first occurred after 20 weeks of gestation in 2020, with systolic blood pressure >=140mmHg and/or diastolic blood pressure >=90mmHg. Gestational diabetes mellitus (IADPSG standard, with one abnormal OGTT); FGR(Fetal estimated weight 95th percentile) 2. Control group: Healthy pregnant women (age +/-3 years, gestational weeks +/-1 week matched)
Exclusion criteria
Exclusion criteria: 1.Multiple pregnancies; 2. Fetal structural malformations; 3. Severe infection or immune disease of the mother
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetal pulmonary microvascular perfusion;Fetal pulmonary stiffness and viscosity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fetal growth and development parameters; | — |
Countries
China
Contacts
Public ContactGuorong Lv
The Second Affiliated hospital of Fujian Medical University
Outcome results
None listed