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Intermittent hypoxia aggravates periodontitis by regulating subgingival microbiota, metabolites, and activating related signaling pathways

Intermittent hypoxia aggravates periodontitis by regulating subgingival microbiota, metabolites, and activating related signaling pathways

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113661
Enrollment
Unknown
Registered
2025-12-01
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

OSA with periodontitis group:None
Non-OSA with periodontitis group:None

Sponsors

School of Stomatology, Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 25 and 55; 2. It was diagnosed as stage II periodontitis according to the classification of the American Periodontal Association (AAP) and the European Periodontal Association (EFP) in 2018. 3. Self-report no history of alcohol abuse; 4. Self-reporting that one has never smoked or has quit smoking for more than six months.

Exclusion criteria

Exclusion criteria: 1. Special dietary preferences, pet feeding, systemic diseases (hypertension, diabetes, etc.), salivary gland diseases, oral mucosal infectious diseases, untreated dental caries or pericoronitis, and the use of antibiotics or hormone drugs within the past 3 months 2. Received periodontal and/or OSA treatment within the past month.

Design outcomes

Primary

MeasureTime frame
Alpha and beta diversity ;OPLS-DA analysis ;—

Countries

China

Contacts

Public ContactChen Hui

School of Stomatology, Shandong University

h.chen@sdu.edu.cn+86 155 6266 1031

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026