Postoperative pain after gynecological tumor surgery
Conditions
Interventions
Intravenous Analgesia Pump Group:150 ug Sufentanil + 150 mg Flurbiprofen Ester + 30 mg Esketamine + 75 ug Dexmedetomidine + normal saline, diluted to a total volume of 150 ml. Patient-Controlled Intra
Epidural Analgesia Pump Group:125 ug Sufentanil + 300 mg Ropivacaine + normal saline, diluted to a total volume of 250 ml. Patient-Controlled Epidural Analgesia (PCEA) with a background infusion rate
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 70 2.ASA Class I-II 3. Gynecological malignant tumor surgery will be opened at an appropriate time 4.BMI < 35
Exclusion criteria
Exclusion criteria: 1.Inability to provide informed consent, unable to communicate. 2.Contraindications to epidural anesthesia. 3.Glaucoma. 4.Resting heart rate 160/100 mmHg. 6.History of psychiatric disorder. 7.History of cardiovascular events such as heart failure, myocardial infarction, aortic dissection, or aneurysm. 8.Second or third-degree atrioventricular block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of VAS scores over 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score of patients in PACU;Patient's medication use in the PACU;Nausea and Vomiting VAS score at 28 hours after surgery.;RASS score at 28 hours after surgery.;Postoperative Day 2 (POD2) Pain VAS;Postoperative Day 2 (POD2) Nausea/Vomiting VAS;Postoperative Day 2 (POD2) RASS scores.;Postoperative Day 3 Pain VAS score;Postoperative Day 3 QoR-15 score;Postoperative Day 2 Richards-Campbell Sleep Questionnaire (RCSQ) score;Time to first flatus; | — |
Countries
China
Contacts
Public ContactJun Zhang
Fudan University Shanghai Cancer Center
Outcome results
None listed