Helicobacter pylori infection
Conditions
Interventions
VAB-7 group:Vonoprazan 20mg twice daily+Amoxicillin 1g three times daily+Bismuth 220mg twice daily for 7 days
VA-14 group:Vonoprazan 20mg twice daily and Amoxicillin 1g three times daily for 14 days
Sponsors
The First Affiliated Hospital with Nanjing Medical University(Jiangsu Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 70 years, regardless of sex. 2.Helicobacter pylori infection confirmed by ¹³C or ¹4C urea breath test within 1 month before enrollment. 3.Chronic gastritis with H. pylori infection confirmed by endoscopy within 3 months, meeting the indications for eradication therapy in the Sixth National Consensus Report on the Management of Helicobacter pylori Infection (China), and willing to receive eradication treatment. 4.No prior H. pylori eradication therapy. 5.Written informed consent before participation.
Exclusion criteria
Exclusion criteria: 1.Known allergy or hypersensitivity to any study medication (vonoprazan, amoxicillin, or bismuth). 2.Use of potassium-competitive acid blockers (P-CABs), proton pump inhibitors (PPIs), H2 receptor antagonists, antibiotics, bismuth preparations, or probiotics within 4 weeks before enrollment. 3.Pregnant or lactating women. 4.Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or anticoagulants during the study period. 5.Presence of serious comorbid conditions that may interfere with study evaluation, including significant cardiac, pulmonary, hepatic, renal, metabolic, or psychiatric disorders, or malignancy. 6.History of gastric or esophageal surgery. 7.Any condition or factor that may affect compliance or make it difficult for the subject to complete follow-up as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;Compliance;Cost-effectiveness; | — |
Countries
China
Contacts
Public ContactFeng Ye
Department of Gastroenterology, Jiangsu Provincial People's Hospital
Outcome results
None listed