Psychomotor Function: Refers to the abilities related to psychological states and motor control, encompassing aspects such as motor coordination, reaction time, attention and concentration, memory and learning capacity, and executive functions.
Conditions
Interventions
Intervention group:Intravenous administration of esketamine 0.25mg/kg in combination with propofol 2mg/kg for induction of anesthesia
Control group:Intravenous administration of sufentanil 0.1 µg/kg in combination with propofol 2 mg/kg for induction of anesthesia
Sponsors
Ningbo Hangzhou Bay Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Scheduled for painless induced abortion surgery under intravenous anesthesia; 2. ASA Physical Status Class I or II; 3. Aged 18-40 years; 4. Body Mass Index (BMI) 18-28 kg/m^2; 5. Gestational age < 14 weeks, confirmed by ultrasound and human chorionic gonadotropin (hCG) testing; 6. Signed informed consent form with voluntary participation in the study.
Exclusion criteria
Exclusion criteria: 1. Cardiopulmonary diseases; 2. Acute upper respiratory tract infection (active or recent recovery phase); 3. Abnormal liver or kidney function; 4. Alcohol abuse; 5. Obstructive sleep apnea-hypopnea syndrome (OSAHS); 6. Long-term use of sedatives/opioids/antidepressants; 7. History of anesthesia allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychomotor function: Digit Symbol Substitution Test (DSST) scores at 30 minutes after emergence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Digit Symbol Substitution Test scores at 60 and 90 minutes after emergence, and Trieger Dot Test (TDT) scores at 30, 60, and 90 minutes after emergence;Postoperative emergence time;PACU recovery status: Post-anesthesia recovery score assessed by Aldrete scale;Adverse reactions: Record the incidence of injection pain, hypoxemia, hypotension, nausea and vomiting, (psychiatric symptoms,) and agitation during the recovery period in the perioperative period.;Intraoperative recording parameters: total dosage of anesthetic agents, time of anesthesia initiation and termination, time of surgery initiation and termination, vital signs (MAP, HR) after anesthesia induction, during uterine evacuation, and at the end of anesthesia, as well as the frequency of body movement and jaw thrust interventions.;On postoperative day 1 and day 3, the QoR-15 scale will be used to assess postoperative recovery status.; | — |
Countries
China
Contacts
Public ContactFazhan Ma
Ningbo Hangzhou Bay Hospital
Outcome results
None listed