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Precision stratification research on bladder cancer immunotherapy based on TLS spatiotemporal atlas and mechanics biomarkers

Precision stratification research on bladder cancer immunotherapy based on TLS spatiotemporal atlas and mechanics biomarkers

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113651
Enrollment
Unknown
Registered
2025-12-01
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bladder cancer

Interventions

Observation group:None

Sponsors

Shanghai Tenth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Above 18 years old; 2. Clinically and pathologically diagnosed with bladder cancer (NMIBC or MIBC), and planned to receive/are currently receiving/already received the following immunotherapies: immune checkpoint inhibitors (PD-1/PD-L1, etc.) / BCG system treatment; 3. Good compliance and willing to cooperate in sample collection.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with severe uncontrolled underlying diseases or acute infections; 3. Patients who cannot understand the purpose of the study or refuse to comply with the study requirements; 4. Those without legal capacity or whose legal capacity is restricted; 5. Researchers judge that the patients have poor compliance and cannot cooperate in sample collection; 6. Any medical history, as judged by the researchers, may interfere with the test results or increase the risks for the patients.

Design outcomes

Primary

MeasureTime frame
After receiving treatment with immune checkpoint inhibitors (such as PD-1/PD-L1) or BCG system, OS and DFS/PFS;

Secondary

MeasureTime frame
Objective response rate, ORR;Disease control rate, DCR;

Countries

China

Contacts

Public ContactBing Shen

Shanghai Tenth People's Hospital

urodrshenbing@shsmu.edu.cn+86 21 6630 0588

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026